Endocrine Abstracts

The full-length retinoblastoma interacting zinc-finger protein (RIZ), codified by ten exons, has tumour suppressive and differentiating properties and is known to be a downstream effector in classical oestrogen target tissue. In many normal and malignant tissues alternative splicing isoforms, RIZ1 and RIZ2, frame-shift mutations and/or exon deletions have been found, but their oncogenic role is still debated. Although the presence of RIZ1 in the testis has been described, in g...